Getformin Tablets
Also for the Glimepiride antihyperglycemic agents with complementary mechanisms of action to improve glycemic control to in patients with type 2 diabetes Chemically glimepinde is known as 1-p-12-13-ehyl-4-methyl-2- 3-pyrroline-1-carboxamidojethylphenyl)-sulfonyl)-3-(trans-4- methylcyclohexyl urea having was molecular formula of CHINOS and a structural Chemically metformin HCI known as 1,1-dimethyl biguanide hydrochloride having a molecular formula of C.H.N.Hand structural.
QUALITATIVE & QUANTITATIVE COMPOSITION:
GETFORMIN (Glimepinde Matformin HCl) is available for oral administration at
1. GETFORMIN Tablets 1mg 500mg Each film-coated tablet contaiha
Glimepiride USP 1mg
Metformin HCI USP 500mg
2. GETFORMIN Tablets 2mg+500mg
Also Each lin-coated tablet contains Glimepiride USP 2mg
Metformin HCI USP 500mg
CLINICAL PHARMACOLOGY Mechanism of Action:
Glimepiride:
Glimepiride is a third generation sulphonylurea. The primary mechanism of action of glimepiride appears to be dependent on stimulating the release of insulin from fanctioning pancreatic bela cells.
In addition, extrapancreatic effects (eg. reduction of basal hepatic glucose production and increased peripheral tissue sensitivity to insulin and glucose uptake) may also play role in the activity of
Metformin hydrochloride is a biguanide anti-diabetic, which improves glucose tolerance in patients with type 2 diabetes, lowering both basat and postpraridial plasma glucose. Its mode of action is thought to be thuitifactoral and includes delayed uptake of glucose from the intestinal tract, increased peripheral glucose utilization mediated by Increased insulin sensitivity and inhibition of increased hepatic and renal gluconeogenesis
Sulfonylureas and biguanides act complementary to each other. Both compounds have an additive anti-hyperglycemic effect without increasing the adverse effects of either pharmacological class Pharmacokinetics
The oral bioavailability is approximately 100%. Peak plasma concentrations occur in 2-3 hours. the drug is bound to plasma proteins. Glimepiride is completely metabolized by coxidative biotransformation into two main metabolites, a hydroxy derivative and a carboxy derivative
The half-life after multiple doses is about 9 hours.
Metformin hydrochloride is slowly and incompletely absorbed from
The Also reported to be a 50%
Special Populations
Renar imperment
Gimepinde Gimepinite serum levels decreased as renal function decreased
Mean unnary excretion of metaboltes as
Metformin HC
Also exerose to patients with type improve glycemic constrol in
responded to glimepinde or metformin alone and require additional glycemic control
The maximum daily dose of metformin is 2000mg and of glimepiride Bing The tablets should be swallowed whole and not Crustiedon chend The tablet is taken once daily with meals to s maximum of 4 tablets/day or as directed by .
Getformin ADVERSE REACTIONS:
Diarrhea, vomiting metallic taste, rash, isolated transaminase elevations cholestatic jaundice, allergic sun reactions, photosensitivity
Also reactions, leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemis, aplastic anemia, pancytopenia an Glimepiride appears to be associated with a low incidence of hypoglycemia. It to have low propensity to cause adverse cardiovascular effects. Impaired gastrointestinal absorption of vitamin B and folic acid has been associated with long term metformin therapy. Rarely, metformin administration has resulted in lactic acidosis
The Patients with known hypersensitivity to sulfonylurea or biguanide
or any component of the drug. Insulin-dependent diabetes mellitus
Renal or hepatic failure.
Alcoholism
NIDDM complicated by severe ketosis and acidosis
Diabetic pre-coma end coma
Chronic obstructive pulmonary disease Coronary heart disease, cardiac failure
Peripheral vascular disease
Pregnancy and lactation
PRECAUTIONS:
General
Common the was Increased appartile, euphong mood conflaget, milatility, decreased Wbido dieorientation tation insomnia aturia, abnormal coordination, tremor, dysartuta memory ampaimant, disturbance diar in attention, paraesthesia, sedation, balance discoder, lethargy, headache, blurred vision, diplopia verigo, vening, dry mouth constipation, fatulence, erecttle dysfunction, galt abnomat, feng drunk, latigue, peripheral and weight uncreated
Uncommon Nastipharyngitis, anorexia, hypoglycemia, hallucination, panic tation, depression, depressed mood, mood swings. attack, redlessness, agitati wond
creatinine incrashed and weight decreased
CONTRAINDICATIONS:
egatwin or any the component of the product Patients with rare hereditary problems of galactose molerance, the Lapp glucose-galactise malabsorption should not take this stase deficiency of
inctas medicine
ALso was the Pregabalin the associated weight gam is related the dose and duration of exposure. Some diabetic patients who gain weight on pregabalin treatment may need to
adjust hypoglycemic medications
Also the There have been reports of congestive heart failure in some patients receiving
pregabalin.
Effects on Ability to Drive and Use Machines and Injuries:
There are no adequate and well-controlled studies in pregnant women.
where concort Heatw optates or benzodiazepines should tre dlive CN sects
gabalin my petan Pregaba There a
pregabalin cop
Pregabalin appears to function caused by addiove axycodone
overdoes include of coma
Treatment the was and mory include harodialys if necessary
permitted between nsione perm 15°C-30°C)
the was night and moisture Protect frotters to the The expinton product correctly stored
wilable in blister pack of 14 100mg are avail GABICA (Pregabalin) Capsules 150mg are available in blister pack of GABICA Pregabain) Capsules GABICA (Pregaban) Capsules 300mg are available in blister peck of 14
Keep out of reach of children.
GGetzhttps://luckasluck.click/ciprofloxacin-composition/
pharma (PVTILIMITED www.getzaharms.com.
29-30/27, KIA, Karachi, Pakistan.
L03-
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