DURAGESIC Tablets

Each tablet contains:

Orphenadrine Citrate 35mg

Paracetamol 450mg

Tabros specs

Duragesic Forte Tablets:

Each tablet contains:

Orphenadrine Citrate Paracetamol 50mg 650mg

Tabros specs

THERAPEUTIC INDICATIONS:

Tension headache,

occipital headaches associated with spasm of skeletal muscles in the region of the head and neck. Acute and traumatic conditions of the limbs and trunk: sprains, strains, whiplash injuries, acute torticollis, prolapsed intervertebral disc.

DOSE AND METHOD OF ADMINISTRATION:

The usual dose of Duragesic Tablets is 2 tablets two to three times daily.

The usual dose of Duragesic Forte Tablets is 1 tablet two to three times daily.

CONTRAINDICATIONS:

* Glaucom

* Prostatic hypertrophy or obstruction at the bladder neck,

Myasthenia gravis

* Oesophageal spasm and pyloric or duodenal obstruction. • Hypersensitivity to paracetamol or orphenadrine citrate.

WARNINGS AND PRECAUTIONS:

Orphenadrine citrate should be used with caution in patients with tachycardia, cardiac decompensation, coronary insufficiency or cardiac arrhythmias.

Paracetamol should be used with caution in patients with hepatic or renal dysfunction.

Concomitant treatment with other medicines that contain orphenadrine or paracetamol is not recommended. Safety of continuous long-term therapy with orphenadrine has not been established. Therefore if orphenadrine is prescribed for prolonged use, periodic monitoring of blood, urine and liver function is recommended.

ڈیوراجیک ٹیبلیٹس ۲۵۰/۳۵ ملی گرام . اور لینا ڈرین سٹریٹ + پیراسیٹامول)

ڈیورا جیسک فورٹ ٹیبلیٹس ۱۵۰/۵۰ می گرام

اور فینا ڈرین سٹریٹ + پیراسیٹامول)

Use in the elderly:

ALso was The elderly should be advised to take a reduced dosage as they may be more susceptible to anticholinergic side effects

at regular doses.

Paediatric use:

DRUG INTERACTIONS:

Paracetamol may increase chloramphenicol concentrations. The likelihood of paracetamol toxicity may be increased by the concomitant use of enzyme inducing agents such as alcohol or anticonvulsant medicines..

FERTILITY, PREGNANCY AND LACTATION:

ALSO Effects on fertility:

No data available

Use in pregnancy:

Pregnancy Category B2

ADVERSE EFFECTS:

Adverse effects are mainly due to the anti-cholinerg

Orphenadrine citrate:

More common reactions:

ALSO WAS The known adverse effects include, dryness of the mouth, tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilation of the pupils, increased ocular tension, weakness, nausea, headache, dizziness, constipation and drowsiness. These effects can usually be eliminated by re

Less common reactions:

Sedation, skin rashes and other allergic reactions are very uncommon adverse effects. Infrequently an elderly patient may experience some degree of mental confusion. Very rare cases of aplastic anaemia associated with the use of orphenadrine have been reported.

Paracetamol:

OVERDOSE:

Orphenadrine overdosage:

Known symptoms of overdose with orphenadrine include tachycardia, excitement, confusion and delirium leading to coma. Convulsions, dilated pupils and urinary retention may occur.

Paracetamol overdosage:

Overdose of paracetamol can result in severe liver damage and sometimes acute renal tubular necrosis.

ALso was Toxic symptoms following an overdose with paracetamol include vomiting, abdominal pain, hypotension, sweating, central stimulation with exhilaration and convulsions in-children, drowsiness, respiratory depression, cyanosis and coma. In adults, hepatotoxicity may occur after ingestion of a single dose of paracetamol 10 to 15g; a dose of 25g or more is potentially fatal.

Symptorns during the first two days of acute poisoning by paracetamol do not reflect the potential seriousness of the Intoxication. Major manifestations of liver failure such as jaundice, hypoglycaemia and metabolic acidosis may lake al least three days to develop.

Treatment:

ALso was Prompt treatment is essential even when there are no obvious symptoms. In cases, of overdosage, methods of reducing absorption of ingested medicine are important. Prompt administration of activated

Convulsions and delirium respond to relatively large doses of diazepam, preferably by mouth. Adequate hydration of the patient is important.

PHARMACOLOGICAL PROPERTIES:

Mechanism of action:

Orphenadrine is a skeletal muscle relaxant. Paracetamol is an analgesic and antipyretic.

PRECLINICAL SAFETY DATA:

Genotoxicity:

No data available.

Carcinogenicity: No data available.

PRESENTATION:

Duragesic Tablets: Blister strip of 10×10’s in a carton. Duragesic Forte Tablets: Blister strip of 3×10’s in a carton.

INSTRUCTIONS:

Protect from sunlight & moisture. Store below 30°C.

Keep all medicines out of reach of children.

Dosage: As directed by the Physician. For oral use only.

ہدایات :-

صرف رجسرا میڈیکل پر یشر کے لئے پر فروخت کے لئے۔ دوا کو سورج کی روشنی اور تجھی سے محفوظ رکھیں ۔ وا کو ۳۰ ڈگری سینٹی گریڈ سے کم درجہ حرارت پر رکھیں۔ تمام دوا میں بچوں کی پہنچ سے دور رکھیں۔ خوراک : ڈاکٹر کی ہدایت کے مطابق۔ صرف کھانے کے لئے۔

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DURAGESIC Tablets